The consensus seems to be to take Transcendence to get from TT10 to 14. That’s what I did 2yrs ago, getting close to TT24 now. In the late game Compendia seem the way to go, to boost your science to insane levels. Which sounds nice, but I don’t have enough Chronospheres for that yet. Last year I was in a strange game state because of a true 40k run, so I picked burned paragon. Due to limited time to play actively, that run is still ongoing (true year 56442 atm :D), but I plan to reset soonish.

So, my question now is: What’s the best mid-game pick? I’m considering:

• 1500 burned paragon again sounds solid, I’m at roughly 500/4600 (with another 1k+ after reset)
• I’m at 90k Karmakittens, so another 25*25k = 625k would also make a difference (roughly +344 Karma, which currently sits at only around 180). But then again, happiness (900%-ish) is not super important at this stage, since it does not affect space. Could help with religion though.

Everything else seems irrelevant (e.g. +2k TC, when I have many tens of millions) or impossible (e.g. Metaphysics, which are already unlocked). Unless there is some obvious choice I’m overlooking.